Synergistic action of Erigeron annuus L. Pers and Borago officinalis L. enhances anti-obesity activity in a mouse model of diet-induced obesity
作者: Yulong ZhengJaesun LeeKyong-Oh ShinKyungho ParkIl-Jun Kang
作者单位: 1Department of Food Science and Nutrition, Hallym University, Chuncheon 24252, Republic of Korea
刊名: Nutrition Research, 2019, Vol.69 , pp.58-66
来源数据库: Elsevier Journal
DOI: 10.1016/j.nutres.2019.07.002
关键词: ObesityExtract mixtureWeight lossTranscription factorC57BL/6 J mice
英文摘要: Abstract(#br)Prior studies show that Borago officinalis L. (BO) can suppress lipid accumulation in 3 T3-L1 adipocytes. Similarly, we recently revealed that Erigeron annuus L. Pers (EA) can significantly diminish both lipid accumulation and adipocyte differentiation in 3 T3-L1 cells through an AMPK (AMP-activated protein kinase)-dependent mechanism. Accordingly, the objective of this present study was to evaluate the anti-obesity activity of EA and/or BO using an animal model of obesity. Obesity was induced in C57BL/6 J mice by feeding a high-fat diet (HFD; 60 kcal% fat) for 3 weeks, followed by administration of EA and/or BO (100-200 mg/kg body weight) or positive control Garcinia Cambogia (GC) (100 mg/kg body weight) for an additional 8 weeks. The anti-obesity effect of EA and/or BO was...
全文获取路径: Elsevier  (合作)
影响因子:2.142 (2012)

  • obesity 肥胖
  • induced 感应的
  • mouse 小鼠
  • factor 因素
  • activity 活度
  • action 行为
  • mixture 混合物
  • model 模型