Thermosensitive, fast gelling, photoluminescent, highly flexible, and degradable hydrogels for stem cell delivery
作者: Hong NiuXiaofei LiHaichang LiZhaobo FanJianjie MaJianjun Guan
作者单位: 1Department of Materials Science and Engineering, The Ohio State University, 2041 College Road, Columbus, OH, USA
2Department of Surgery, The Ohio State University, Columbus, OH 43210, USA
3Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO 63130, USA
刊名: Acta Biomaterialia, 2019, Vol.83 , pp.96-108
来源数据库: Elsevier Journal
DOI: 10.1016/j.actbio.2018.10.038
关键词: Fast gelling hydrogelsPhotoluminescent hydrogelsCell retentionReal-time cell trackingStem cell therapy
英文摘要: Abstract(#br)Stem cell therapy is a promising approach to regenerate ischemic cardiovascular tissues yet experiences low efficacy. One of the major causes is inferior cell retention in tissues. Injectable cell carriers that can quickly solidify upon injection into tissues so as to immediately increase viscosity have potential to largely improve cell retention. A family of injectable, fast gelling, and thermosensitive hydrogels were developed for delivering stem cells into heart and skeletal muscle tissues. The hydrogels were also photoluminescent with low photobleaching, allowing for non-invasively tracking hydrogel biodistribution and retention by fluorescent imaging. The hydrogels were polymerized by N-isopropylacrylamide (NIPAAm), 2-hydroxyethyl methacrylate (HEMA),...
全文获取路径: Elsevier  (合作)
影响因子:5.093 (2012)

  • retention 保留
  • gelling 胶凝
  • flexible 接电绳
  • tracking 跟踪
  • highly 高度地
  • delivery 移交
  • therapy 治疗