Antileishmanial activity and chemical composition from Brazilian geopropolis produced by stingless bee Melipona fasciculata
作者: Richard Pereira DutraJeamile Lima BezerraMayara Cristina Pinto da SilvaMarisa Cristina Aranha BatistaFernando José Brito PatrícioFlavia Raquel Fernandes NascimentoMaria Nilce Sousa RibeiroRosane Nassar Meireles Guerra
作者单位: 1Laboratório de Farmacognosia, Centro de Ciências Biológicas e da Saúde, Universidade Federal do Maranhão, São Luís, MA, Brazil
2Laboratório de Imunofisiologia, Centro de Ciências Biológicas e da Saúde, Universidade Federal do Maranhão, São Luís, MA, Brazil
刊名: Revista Brasileira de Farmacognosia, 2019, Vol.29 (3), pp.287-293
来源数据库: Elsevier Journal
DOI: 10.1016/j.bjp.2019.02.009
关键词: ApidaeMeliponiniGeopropolisLeishmaniasisGallic acidEllagic acid
原始语种摘要: Abstract(#br)Geopropolis is produced by some stingless bee species such as Melipona fasciculata and consists of a mixture of plant resins, salivary secretions of the bee, wax, and soil. This study evaluated the antileishmanial activity in vitro , cytotoxicity and chemical composition of geopropolis produced by M. fasciculata in the savannah region of Maranhão, Brazil. The geopropolis extract was obtained through maceration using in 70% ethanol. The hydroalcoholic extract of geopropolis after liquid–liquid partition yielded the hexane, chloroformic, ethyl acetate and hydroalcoholic fractions. Antileishmanial activity was evaluated against promastigote and intracellular amastigote of Leishmania amazonensis . Cytotoxic was realized in BALB/c mice peritoneal macrophages. Chemical analysis was...
全文获取路径: Elsevier  (合作)
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关键词翻译
关键词翻译
  • gallic 制图布
  • activity 活度
  • acetate 醋酸盐
  • amastigote 无鞭毛体
  • produced 出品
  • Leishmania 利什曼虫
  • extract 提取
  • chemical 化学的
  • promastigote 前鞭毛体
  • murine 鼠灰色