Serum TEM5 and TEM7 concentrations correlate with clinicopathologic features and poor prognosis of colorectal cancer patients
作者: Łukasz PietrzykPaulina Wdowiak
作者单位: 1Department of Didactics and Medical Simulation, Chair of Anatomy, Medical University of Lublin, Lublin, Poland
2Department of General, Oncological and Minimally Invasive Surgery, 1stMilitary Clinical Hospital with the Outpatient Clinic, Lublin, Poland
3Chair and Department of Human Anatomy, Medical University of Lublin, Lublin, Poland
刊名: Advances in Medical Sciences, 2019, Vol.64 (2), pp.402-408
来源数据库: Elsevier Journal
DOI: 10.1016/j.advms.2019.07.001
关键词: Tumour endothelial marker 5Tumour endothelial marker 7Colorectal cancerBiomarkerScreening
原始语种摘要: Abstract(#br)Purpose(#br)Colorectal cancer (CRC) is a serious threat worldwide; therefore, discovering sensitive and specific serum biomarkers for early stages of CRC is a great challenge. In this study, we evaluated whether tumour endothelial marker 5 (TEM5) and 7 (TEM7) circulating in blood serum can be useful as blood-based markers for detection, progression, and prognosis in CRC patients. Moreover, their specificity and sensitivity in the early diagnosis of CRC were compared with common carcinoma diagnostic markers, i.e. CEA and Ca 19-9.(#br)Materials and methods(#br)The study included 45 CRC patients and 35 healthy individuals. The serum concentration of TEM5 and TEM7 were quantified using sandwich ELISA.(#br)Results(#br)The mean TEM5 and TEM7 serum concentrations were statistically...
全文获取路径: Elsevier  (合作)

  • prognosis 预报
  • TEM Illustrated Tool and Equipment Manual
  • markers 时标
  • concentrations 浓聚物
  • cancer 癌症
  • colorectal 结肠直肠的
  • stage 
  • serum 血清
  • survival 生存
  • significantly 较大地