Geopropolis gel for the adjuvant treatment of candidiasis – formulation and in vitro release assay
作者: Umberto Pereira Souza JúniorSonia Pereira CabreraTelma Maria Guedes da SilvaEva Monica Sarmento da SilvaCelso Amorim CamaraTania Maria Sarmento Silva
作者单位: 1Departamento de Química, Universidade Federal Rural de Pernambuco, Recife, PE, Brazil
2Colegiado de Zootecnia, Universidade Federal do Vale de São Francisco, Petrolina, PE, Brazil
刊名: Revista Brasileira de Farmacognosia, 2019, Vol.29 (3), pp.278-286
来源数据库: Elsevier Journal
DOI: 10.1016/j.bjp.2019.02.010
关键词: GeopropolisMelipona subnitidaJandaíraFlavonoidsDelivery systemCandidiasis
原始语种摘要: Abstract(#br)The geopropolis produced by the stingless bee Melipona subnitida (popularly called “jandaíra” in Brazil) is a mixture of resin, wax, and mud. This study analyzed the antifungal activity of the geopropolis extract from Candida spp., developed a gel formulation with this extract and analyzed the delivery of bioactives (kinetics release) in the formulation and their chemical profile by UHPLC-PDA-qTOF-MS/MS. Three different gels were prepared using the geopropolis extract, carbomer, propylene glycol, and water. Formulations with different amounts of propylene glycol were investigated. Physical, visual, pH, viscosity, adhesion, spreadability, leakage, and in vitro release tests were performed in the proposed formulations. Antifungal tests with the geopropolis ethanolic extract...
全文获取路径: Elsevier  (合作)

  • release 释放
  • candidiasis 念珠菌病
  • formulation 配方
  • adjuvant 辅助剂
  • extract 提取
  • chalcones 查耳酮
  • flavanone 黄烷酮
  • cellulose 纤维素
  • flavonol 黄酮醇
  • flavonoids 黄酮类似物