Relevance of tumour-infiltrating lymphocytes, PD-1 and PD-L1 in patients with high-risk, nodal-metastasised breast cancer of the German Adjuvant Intergroup Node–positive study
作者: Aurelia NoskeVolker MöbusKarsten WeberSabine SchmatlochWilko WeichertClaus-Henning KöhneChristine SolbachBarbara Ingold HeppnerKatja SteigerVolkmar MüllerPeter FaschingThomas KarnMarion van MackelenberghFrederik MarméWolfgang D. SchmittChristian SchemElmar StickelerSybille LoiblCarsten Denkert
作者单位: 1Institute of Pathology, Technical University of Munich, School of Medicine, Germany
2Department of Gynecology and Obstetrics, Hospital Frankfurt Höchst, Academic Hospital of the University Frankfurt, Germany
3German Breast Group (GBG), Neu-Isenburg, Germany
4Breast Unit, Elisabeth-Krankenhaus Kassel, Kassel, Germany
5Department of Oncology, University Hospital Oldenburg, Oldenburg, Germany
6Department of Gynecology and Obstetrics, University Hospital Frankfurt, Germany
7Institute of Pathology, Charité University Hospital, Berlin, Germany
8Institute of Pathology, DRK Kliniken Berlin, Germany
9Department of Gynecology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
10Department of Gynecology and Obstetrics, University Hospital Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany
11University Hospital Schleswig-Holstein, Kiel, Germany
12Department of Gynecology and National Center for Tumor Diseases (NCT), Heidelberg, Germany
13Breast Unit Krankenhaus Jerusalem, Hamburg, Ger
刊名: European Journal of Cancer, 2019, Vol.114 , pp.76-88
来源数据库: Elsevier Journal
DOI: 10.1016/j.ejca.2019.04.010
关键词: Breast cancerAdjuvantTILsPD-1PD-L1PrognosisTherapy prediction
英文摘要: Abstract(#br)Background(#br)Immune cell infiltration in breast cancer is important for the patient's prognosis and response to systemic therapies including immunotherapy. We sought to investigate the prevalence of tumour-infiltrating lymphocytes (TILs) and their association with immune checkpoints such as programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) in high-risk, node-positive breast cancer of the adjuvant German Adjuvant Intergroup Node–positive (GAIN-1) trial.(#br)Patients and methods(#br)We evaluated TILs by haematoxylin and eosin staining and PD-1 and PD-L1 (SP263 assay) expression by immunohistochemistry in 1318 formalin-fixed, paraffin-embedded breast carcinomas. The association of TILs with PD-1, PD-L1, molecular intrinsic subtypes, outcome and therapy...
全文获取路径: Elsevier  (合作)
影响因子:5.061 (2012)

  • infiltrating 浸润的
  • breast 胸部
  • nodal 部件的
  • tumour 肿瘤
  • German 德国人
  • cancer 癌症