Anxiolytic-like and proneurogenic effects of Trichilia catigua ethyl-acetate fraction in mice with cerebral ischemia
作者: Lígia Mendes SoaresJoão Paulo Colhado FerreiraHumberto MilaniRenata LonghiniJoão Carlos P. MelloCelso Vataru NakamuraRúbia Maria Weffort de Oliveira
作者单位: 1Departamento de Farmacologia e Terapêutica, Universidade Estadual de Maringá, Maringá, PR, Brazil
2Departamento de Farmácia, Universidade Estadual de Maringá, Maringá, PR, Brazil
3Departamento de Ciências Básicas da Saúde, Universidade Estadual de Maringá, Maringá, PR, Brazil
刊名: Revista Brasileira de Farmacognosia, 2019, Vol.29 (5), pp.613-620
来源数据库: Elsevier Journal
DOI: 10.1016/j.bjp.2019.04.007
关键词: Trichilia catigua ethyl-acetate fractionBilateral common carotid occlusionAnxietyNeurogenesis
原始语种摘要: Abstract(#br)Trichilia catigua A. Juss., Meliaceae, known as “catuaba” in Brazil, has been popularly used as a tonic for fatigue, impotence and memory deficits. Previously, we have demonstrated that T. catigua ethyl-acetate fraction exerted antidepressive-like effects in mice. Affective-like symptoms are also well recognized outcome of cerebral ischemia in clinical and preclinical settings. Therefore, here we evaluated the effects of ethyl-acetate fraction on the emotional outcomes and its relation with hippocampal neurogenesis in ischemic mice. Male Swiss mice were subject to the bilateral common carotid occlusion during 20 min. The animals received ethyl-acetate fraction (400mg/kg, orally) 30 min before and once per day during 7 days after reperfusion. Emotional...
全文获取路径: Elsevier  (合作)

  • acetate 醋酸盐
  • fraction 分数
  • ethyl 乙基
  • neurogenesis 神经发生
  • ischemia 局部贫血
  • occlusion 锢囚
  • preclinical 临证前期的
  • ischemic 福尔克曼氏麻痹
  • effects 海员自身物品
  • dentate 锯齿状的