Sesquiterpenes from Curcuma zedoaria rhizomes and their cytotoxicity against human gastric cancer AGS cells
作者: Tae Kyoung LeeDahae LeeSeoung Rak LeeYoon-Joo KoKi Sung KangSang Jeon ChungKi Hyun Kim
作者单位: 1School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea
2Laboratory of Nuclear Magnetic Resonance, National Center for Inter-University Research Facilities (NCIRF), Seoul National University, Gwanak-gu, Seoul 08826, Republic of Korea
3College of Korean Medicine, Gachon University, Seongnam 13120, Republic of Korea
刊名: Bioorganic Chemistry, 2019, Vol.87 , pp.117-122
来源数据库: Elsevier Journal
DOI: 10.1016/j.bioorg.2019.03.015
关键词: Curcuma zedoariaSesquiterpenesNMRGastric cancerCytotoxicity
英文摘要: Abstract(#br)Curcuma zedoaria rhizome (Zingiberaceae) is a well-known traditional medicinal plant used in Ayurvedic and traditional Chinese medicine to treat various cancers. This study aimed to identify the cytotoxic components from C. zedoaria rhizomes that act against gastric cancer, which is the third leading cause of death from cancer worldwide because the MeOH extract of C. zedoaria rhizome was found to show a cytotoxic effect against gastric cancer AGS cells. Repeated column chromatography and semi-preparative HPLC purification were used to separate the components from the C. zedoaria MeOH extract. Two new sesquiterpenes, curcumenol-9,10-epoxide ( 1 ) and curcuzedoalide B ( 2 ), and 12 known related sesquiterpenes ( 3–14 ) were isolated from the C. zedoaria MeOH extract. The...
全文获取路径: Elsevier  (合作)
影响因子:1.732 (2012)

  • gastric 胃的
  • against 反对
  • human 人的
  • cytotoxicity 细胞毒性
  • NMR N-Modular Redundancy
  • cells 麻风细胞
  • cancer 癌症
  • their 他们的