Customized protein glycosylation to improve biopharmaceutical function and targeting
作者: Linde Van LanduytChiara LonigroLeander MeurisNico Callewaert
作者单位: 1VIB-UGent Center for Medical Biotechnology, Belgium
2Department of Biochemistry and Microbiology, Ghent University, Technologiepark 927, B-9052 Gent, Belgium
刊名: Current Opinion in Biotechnology, 2019, Vol.60 , pp.17-28
来源数据库: Elsevier Journal
DOI: 10.1016/j.copbio.2018.11.017
原始语种摘要: For a long time, glycoprotein production has been limited by the inherent properties of production hosts. Glycosylation of biopharmaceuticals has been regarded as a necessary evil, often needed for protein folding or function, but also a source of heterogeneity, complicating downstream processing and product characterization. This has strongly determined the choice of production hosts. Over the last few decades, numerous glycoengineering efforts have helped solving this problem. Moreover, insights from fundamental studies have made it possible to improve therapeutic protein functionality through careful glycoengineering. Here, we will focus on how production host and in vitro glycoengineering approaches allow to design biopharmaceuticals with glycans that impart improved functionality. An...
全文获取路径: Elsevier  (合作)
影响因子:7.86 (2012)

  • glycosylation 糖基化
  • protein 蛋白质
  • targeting 导向目标
  • improve 改进
  • therapeutics 治疗学
  • heterogeneity 不均匀性
  • production 生产
  • glycan 多糖
  • focus 焦点
  • function 函数