Effects of selenium deficiency and low protein intake on the apoptosis through a mitochondria-dependent pathway
作者: Liwei ZhangYanhui GaoHongqi FengNing ZouKewei WangDianjun Sun
作者单位: 1Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Key Lab of Etiology and Epidemiology, National Health and Family Planning Commission (23618504), Harbin, 150086, Heilongjiang, China
刊名: Journal of Trace Elements in Medicine and Biology, 2019, Vol.56 , pp.21-30
来源数据库: Elsevier Journal
DOI: 10.1016/j.jtemb.2019.06.019
关键词: Selenium deficiencyLow protein dietCardiacdysfunctionOxidative stressApoptosisMitochondrial pathway
原始语种摘要: Abstract(#br)Objective(#br)Selenium(Se)is an important trace element for human health. Studies have shown that selenium deficiency and low protein(Pr) intake are the primary risk factors for Keshan disease.The relationship between the cardiac malfunction induced by these two risk factors and the mitochondria-mediated apoptotic pathway is poorly understood.This study aimed to determine the effect of selenium deficiency and low protein intake on the mitochondria-mediated apoptotic pathway.(#br)Methods(#br)In the present study, 120 weaning Wistar rats were randomly fed one of six different diets. The myocardial tissue sections were deparaffinized in water and subjected to hematoxylin-eosin staining. Mitochondrial changes in the myocardial tissue were observed and photographed using an H-7650...
全文获取路径: Elsevier  (合作)

  • selenium 
  • intake 收气
  • protein 蛋白质
  • mitochondria 线粒体
  • pathway 轨道
  • deficiency 不足
  • myocardial 心肌的
  • capability 能力
  • peroxidase 过氧物酶
  • oxidizing 氧化