Granular hydrogels: emergent properties of jammed hydrogel microparticles and their applications in tissue repair and regeneration
作者: Lindsay RileyLucas SchirmerTatiana Segura
作者单位: 1Department of Biomedical Engineering, Duke University, United States
2Department of Dermatology, Duke University, United States
3Department of Neurology, Duke University, United States
刊名: Current Opinion in Biotechnology, 2019, Vol.60 , pp.1-8
来源数据库: Elsevier Journal
DOI: 10.1016/j.copbio.2018.11.001
原始语种摘要: Granular hydrogels are emerging as a versatile and effective platform for tissue engineered constructs in regenerative medicine. The hydrogel microparticles (HMPs) that compose these materials exhibit particle jamming above a minimum packing fraction, which results in a bulk, yet dynamic, granular hydrogel scaffold. These injectable, microporous scaffolds possess self-assembling, shear-thinning, and self-healing properties. Recently, they have been utilized as cell cultures platforms and extracellular matrix mimics with remarkable success in promoting cellular infiltration and subsequent tissue remodeling in vivo . Furthermore, the modular nature of granular hydrogels accommodates heterogeneous HMP assembly, where varying HMPs have been fabricated to target distinct biological processes...
全文获取路径: Elsevier  (合作)
影响因子:7.86 (2012)

  • hydrogel 水凝胶
  • tissue 组织
  • injectable 可注射的
  • scaffold 脚手架
  • constructs 建筑图纸生成系统
  • deliver 输送
  • regeneration 再生
  • granular 粒状的
  • regenerative 再生放大
  • properties 道具