Molecular characterization and expressional modulation of IRAK1 as downstream signaling adaptor molecule of TLR-signaling pathways in Labeo rohita following PAMPs stimulation and bacterial infections
作者: Sushmita SadangiArpita MohantyMahismita PaichhaSuchismita GoudaAshis SahaSurajit DasMrinal Samanta
作者单位: 1ICAR-Central Institute of Freshwater Aquaculture, Kausalyaganga, Bhubaneswar, Odisha, 751002, India
2Laboratory of Environmental Microbiology and Ecology (LEnME), Department of Life Science, National Institute of Technology, Rourkela, Odisha, 769 008, India
刊名: Fish and Shellfish Immunology, 2020, Vol.96 , pp.161-176
来源数据库: Elsevier Journal
DOI: 10.1016/j.fsi.2019.11.064
关键词: Indian major carpLabeo rohitaTLRIRAK1Innate immunity
原始语种摘要: Abstract(#br)Interleukin-1 receptor associated kinase (IRAK1) is one of the crucial signal transduction mediators in TLR/IL-1R signaling pathways in host immune system. To investigate about it in rohu ( Labeo rohita ), one of the economically important freshwater fish species in the Indian subcontinent, we cloned, characterized and analyzed its expression following bacterial infection and pathogens associated molecular patterns (PAMPs) stimulation. The full-length cDNA of rohu IRAK1 (LrIRAK1) consisted of 2765 nucleotide (nt) having an ORF of 2115 nt encoding a polypeptide of 704 amino acids (aa) with a molecular mass of 70.4 kDa. Structurally, LrIRAK1 consisted of twenty-nine helix, twelve strands and forty one coils making one N-terminal death domain (19–94 aa) and a central serine...
全文获取路径: Elsevier  (合作)
影响因子:2.964 (2012)

  • stimulation 激励
  • downstream 顺聊
  • expressional 表情的
  • signaling 发信号
  • adaptor 注料口衬套
  • molecule 分子
  • bacterial 细菌的
  • following 追踪
  • modulation