Nodal Response to Neoadjuvant Chemotherapy Predicts Receipt of Radiation Therapy after Breast Cancer Diagnosis
作者: Oluwadamilola M. FayanjuYi RenGita SunejaSamantha M. ThomasRachel A. GreenupJennifer K. PlichtaLaura H. RosenbergerJeremy ForceTerry HyslopE. Shelley Hwang
作者单位: 1Department of Surgery, Duke University Medical Center, Box 3513, Durham, NC 27710, USA
2Women’s Cancer Program, Duke Cancer Institute, Durham, NC 27710, USA
3Department of Population Health Sciences, Duke University School of Medicine, 215 Morris Street, Durham, NC 27701
4Duke Forge, Duke University, Durham, NC 27710, USA
5Department of Surgery, Durham VA Medical Center, 508 Fulton St, Durham, NC 27705
6Biostatistics Shared Resource, Duke Cancer Institute, Durham, NC 27710, USA
7Department of Radiation Oncology, Duke University Medical Center, Box 3085, Durham, NC 27710, USA
8Radiation Oncology and Imaging, Duke Cancer Institute, Durham, NC 27710, USA
9Duke Global Health Institute, Duke University, Box 90519, Durham, NC 27708, USA
10Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Box 2717, Durham, NC 27710, USA
11Department of Medicine, Duke University Medical Center, Box 3893, Durham, NC 27710, USA
刊名: International Journal of Radiation Oncology, Biology, Physics, 2019
来源数据库: Elsevier Journal
DOI: 10.1016/j.ijrobp.2019.10.039
关键词: AxillaBreast cancerLymph nodesNeoadjuvant chemotherapyPathologic complete responseRadiation
英文摘要: Abstract(#br)Background(#br)Pathologic complete response (pCR) after neoadjuvant chemotherapy (NACT) is associated with improved overall survival (OS) in breast-cancer patients, but it is unclear how post-NACT response influences radiotherapy administration in patients presenting with node-positive disease. We sought to determine whether nodal pCR is associated with likelihood of receiving nodal radiation and whether radiotherapy among patients experiencing nodal pCR is associated with improved OS.(#br)Methods(#br)cN1 female breast cancer patients diagnosed 2010-2015 who were ypN0 (i.e., nodal pCR, n=12,341) or ypN1 (i.e., residual disease, n=13,668) post-NACT were identified in the National Cancer Database. Multivariate logistic regression was used to identify factors associated with...
全文获取路径: Elsevier  (合作)
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  • after 在之后
  • Cancer 巨蟹座