IL-33/ST2 pathway regulates neutrophil migration and predicts outcome in patients with severe alcoholic hepatitis ✩
作者: Florent ArtruMohamed Bou SalehFrançois MaggiottoGuillaume LassaillyMassih NingarhariJulie DemaretLine-Carolle Ntandja-WandjiJean-Paul Pais de BarrosJulien LabreucheElodie DrumezDoumet Georges HelouSébastien DharancyEmilie GantierAxel PérianinSylvie Chollet-MartinRamon BatallerPhilippe MathurinLaurent DubuquoyAlexandre Louvet
作者单位: 1Hôpital Claude-Huriez, Service Maladies de l'Appareil Digestif, CHU Lille, Lille, France
2Université de Lille/Inserm/CHU de Lille, U995 - LIRIC – Lille Inflammation Research Center, Lille, France
3Centre de Biologie-Pathologie, CHU de Lille, Lille, France
4INSERM, LNC UMR 1231, Université de Bourgogne Franche-Comté, Dijon, France
5Département de biostatistiques, CHU de Lille, Lille, France
6Inserm/Université Paris-Sud/Université Paris-Saclay, UMR996, Chatenay-Malabry, France
7Assistance publique-Hôpitaux de Paris, Hôpital Bichat, Laboratoire d'immunologie « Autoimmunité et Hypersensibilités », Paris, France
8Inserm/Faculté de Médecine Xavier Bichat, UMRS-1149, Paris, France
9CNRS, ERL-8252 Centre de Recherche sur l'Inflammation, Paris, France
10Université Paris Diderot, Sorbonne Paris Cité, Laboratoire d'Excellence INFLAMEX, Paris, France
11Division of Gastroenterology, Hepatology and Nutrition, Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA
刊名: Journal of Hepatology, 2019
来源数据库: Elsevier Journal
DOI: 10.1016/j.jhep.2019.12.017
关键词: Alcoholic hepatitisCirrhosisInfectionPolymorphonuclear neutrophilsInterleukin-33Migration
英文摘要: Background & Aims(#br)Severe alcoholic hepatitis (SAH) is associated with a high risk of infection. The IL-33/ST2 pathway is involved in sepsis control but data regarding its role in alcohol-related liver disease (ALD) are lacking. We aimed to characterize the role of IL-33/ST2 in the polymorphonuclear neutrophils (PMNs) of patients with ALD and SAH.(#br)Methods(#br)Serum and circulating neutrophils were collected from patients with SAH, alcoholic cirrhosis and healthy controls. We quantified IL-33/ST2 pathway activity and CXCR2 at baseline and after exposure to IL-33. We also determined the migration capacity of PMNs.(#br)Results(#br)The decoy receptor of IL-33 (soluble ST2 [sST2]) was increased in SAH vs. cirrhosis and controls, demonstrating the defect in this pathway during ALD. The...
全文获取路径: Elsevier  (合作)
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影响因子:9.858 (2012)

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关键词翻译
关键词翻译
  • alcoholic 醇的
  • hepatitis 肝炎
  • pathway 轨道
  • neutrophil 中性白细胞
  • migration 迁移
  • outcome 效果
  • severe 严滥