DGCR8 expression is altered in children with congenital heart defects
作者: Zhikuan GuoBaoping LiPeng TianDan LiYuwei ZhangQun LiTaibing FanJunming YueYuqi Guo
作者单位: 1Henan Provincial People's Hospital, School of Clinical Medicine, Henan University, Zhengzhou, Henan 450003, PR China
2The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, PR China
3Women&infants Hospital of Zhengzhou, Zhengzhou, Henan 450000, PR China
4Department of Gynecology and obstetrics, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan 430015, PR China
5University of Tennessee Health Science Center, Memphis, TN 38163, United States of America
刊名: Clinica Chimica Acta, 2019, Vol.495 , pp.25-28
来源数据库: Elsevier Journal
DOI: 10.1016/j.cca.2019.03.1619
关键词: DGCR8Congenital heart diseaseVentricular septal defectTetralogy of fallot
英文摘要: Abstract(#br)Aim(#br)To explore the correlation of DGCR8 expression in children with congenital heart defects (CHD) and its clinical significance.(#br)Methods(#br)Full blood samples were collected from children with congenital heart disease( n = 40) and healthy children(n = 40), respectively.Real-time PCR was used to detect the expression of DGCR8 in the blood of healthy children and CHD. Myocardial tissues were collected from children with ventricular septal defect (VSD)( n = 25), and tetralogy of Fallot (TOF)( n = 16),. Real-time PCR and Western blotting were used to detect the expression of DGCR8 in myocardial tissues. Analyze the correlation between DGCR8 expression and congenital heart disease.(#br)Results(#br)The expression levels of DGCR8 was significantly lower in CHD than healthy...
全文获取路径: Elsevier  (合作)
影响因子:2.85 (2012)

  • congenital 先天的
  • heart 心脏
  • expression 表示
  • septal 中隔的
  • altered 改变的
  • children 子女
  • disease