Matrix stiffness modulates ILK-mediated YAP activation to control the drug resistance of breast cancer cells
作者: Xiang QinXiaoying LvPing LiRui YangQiong XiaYu ChenYueting PengLi LiShun LiTingting LiYing JiangHong YangChunhui WuChuan ZhengJie ZhuFengming YouHeng WangJiong ChenYiyao Liu
作者单位: 1Department of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, PR China
2Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu 610072, Sichuan, PR China
3Center for Information in Biology, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, PR China
4State Key Laboratory of Pharmaceutical Biotechnology, MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Nanjing University, Nanjing 210061, Jiangsu, PR China
刊名: BBA - Molecular Basis of Disease, 2020, Vol.1866 (3)
来源数据库: Elsevier Journal
DOI: 10.1016/j.bbadis.2019.165625
关键词: Matrix stiffnessILKYAPDrug resistanceMechanotransduction
原始语种摘要: Abstract(#br)One of the hallmarks of cancer progression is strong drug resistance during clinical treatments. The tumor microenvironment is closely associated with multidrug resistance, the optimization of tumor microenvironments may have a strong therapeutic effect. In this study, we configured polyacrylamide hydrogels of varying stiffness [low (10 kPa), intermediate (38 kPa) and high (57 kPa)] to simulate tissue physical matrix stiffness across different stages of breast cancer. After treatment with doxorubicin, cell survival rates on intermediate stiffness substrate are significantly higher. We find that high expression of ILK and YAP reduces the survival rates of breast cancer patients. Drug resistance is closely associated with the inactivation of the hippo pathway protein...
全文获取路径: Elsevier  (合作)