1,25(OH) 2 D 3 attenuates indoxyl sulfate–induced epithelial-to-mesenchymal cell transition via inactivation of PI3K/Akt/β-catenin signaling in renal tubular epithelial cells
作者: Li-Chien ChangHai-Lun SunChia-Han TsaiChia-Wen KuoKai-Li LiuChong-Kuei LiiChin-Shiu HuangChien-Chun Li
作者单位: 1Department of Internal Medicine, Taichung Armed Forces General Hospital, Taichung, Taiwan
2Department of Medicine, National Defense Medical Center, Taipei, Taiwan
3Department of Nutrition, Chung Shan Medical University, Taichung, Taiwan
4Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan
5School of Medicine, Chung Shan Medical University, Taichung, Taiwan
6Department of Nutrition, Chung Shan Medical University Hospital, Taichung, Taiwan
7Department of Nutrition, China Medical University, Taichung, Taiwan
8Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan
刊名: Nutrition, 2020, Vol.69
来源数据库: Elsevier Journal
DOI: 10.1016/j.nut.2019.110554
关键词: 125(OH) 2 D 3Β-cateninEMTHK-2 cellsIndoxyl sulfate
原始语种摘要: Abstract(#br)Objectives(#br)Indoxyl sulfate (IS), a uremic toxin, has been shown to promote the epithelial-to-mesenchymal transition (EMT) of human proximal tubular cells and to accelerate the progression of chronic kidney disease (CKD). Despite the well-known protective role of 1,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ] in EMT, the effect of 1,25(OH) 2 D 3 on IS-induced EMT in human proximal tubular epithelial cells and the underlying mechanism remain unclear. The aim of this study was to determine whether IS (0-1 mM) dose-dependently inhibited the protein expression of E-cadherin and increased the protein expression of alpha-smooth muscle actin, N-cadherin, and fibronectin.(#br)Methods(#br)This study investigated the molecular mechanism by which 1,25(OH) 2 D 3 attenuates IS-induced...
全文获取路径: Elsevier  (合作)
影响因子:2.859 (2012)

  • OH Over-the-Horizon
  • induced 感应的
  • sulfate 硫酸盐
  • tubular 管状的
  • indoxyl 吲羟
  • epithelial 上皮的
  • cells 麻风细胞
  • mesenchymal 间叶细胞的
  • renal 肾的
  • inactivation 失活