Possible Underlying Mechanism for Hydrogen Peroxide-Induced Electromechanical Suppression in Human Atrial Myocardium
作者: Shih-Hurng LohJong-Shiaw JinChien-Sung TsaiChao-Ming ChaoYin TsaiWei-Hwa ChenTzu-Hurng ChengChao-Chin ChuangCheng-I Lin
作者单位: 1Departments of Pharmacology National Defense Medical Center, Nei-Hu P.O. Box 90048-504, Taipei, Taiwan
2Departments of Pathology National Defense Medical Center, Nei-Hu P.O. Box 90048-504, Taipei, Taiwan
3Departments of Surgery National Defense Medical Center, Nei-Hu P.O. Box 90048-504, Taipei, Taiwan
4Departments of Dermatology National Defense Medical Center, Nei-Hu P.O. Box 90048-504, Taipei, Taiwan
5Departments of Gynecology National Defense Medical Center, Nei-Hu P.O. Box 90048-504, Taipei, Taiwan
刊名: Journal of Pharmacological Sciences, 2003, Vol.91 (1), pp.53-60
来源数据库: Elsevier Journal
DOI: 10.1254/S1347-8613(19)32775-6
原始语种摘要: Abstract(#br)Hydrogen peroxide (H 2 O 2 ) and its metabolites have been shown to exert complex effects on the cardiac muscle during cardiac ischemia/reperfusion. The aim of the present study, by perfusing H 2 O 2 or/and different scavengers of oxygen free radicals (OFRs) into the human atrium, is to characterize the electropharmacological effects of H 2 O 2 and explore its possible underlying mechanism. Atrial tissues obtained from the heart of 19 patients undergoing corrective cardiac surgery were used. Transmembrane action potentials were recorded using the conventional microelectrode technique, and contraction of atrial fibers was evaluated in normal [K] o (4 mM) in the absence and presence of tested agents. H 2 O 2 (30 μM-3 mM) had a biphasic effect on the contractile force (an...
全文获取路径: Elsevier  (合作)
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来源刊物:
影响因子:2.15 (2012)

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关键词翻译
关键词翻译
  • scavenger 食腐动物
  • pretreatment 预处理
  • atrium 围鳃腔
  • potential 
  • depolarizing 去极化的消偏振的
  • radical 
  • blocked 分块
  • corrective 修正的
  • biphasic 双相的
  • concentration 浓度