Hypertonic Mannitol for the Prevention of Intradialytic Hypotension: A Randomized Controlled Trial
作者: Finnian R. Mc CauslandBrian ClaggettVenkata S. SabbisettiPetr JarolimSushrut S. Waikar
作者单位: 1Renal Division, Department of Medicine, Brigham and Women’s Hospital, Brigham and Women's Hospital, Boston, MA
2Harvard Medical School, Brigham and Women's Hospital, Boston, MA
3Cardiology Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA
4Department of Pathology, Brigham and Women's Hospital, Boston, MA
刊名: American Journal of Kidney Diseases, 2019
来源数据库: Elsevier Journal
DOI: 10.1053/j.ajkd.2019.03.415
关键词: MannitolOsmolalityIntradialytic hypotension (IDH)HemodialysisHemodynamic instabilityDialysis disequilibriumSystolic blood pressure (SBP)End-stage renal disease (ESRD)Acute kidney injury (AKI)Dialysis initiationKidney injury biomarkerRandomized controlled trial (RCT)
英文摘要: Rationale & Objective(#br)Intradialytic hypotension (IDH) is a common complication at the initiation of hemodialysis (HD) therapy, is associated with greater mortality, and may be related to relatively rapid shifts in plasma osmolality. This study sought to evaluate the effect of an intervention to minimize intradialytic changes in plasma osmolality on the occurrence of IDH.(#br)Study Design(#br)Double-blind, single-center, randomized, controlled trial.(#br)Setting & Participants(#br)Individuals requiring initiation of HD for acute or chronic kidney disease.(#br)Intervention(#br)Mannitol, 0.25g/kg/h, versus a similar volume of 0.9% saline solution during the first 3 HD sessions.(#br)Outcomes(#br)The primary end point was average decline in systolic blood pressure (SBP)....
全文获取路径: Elsevier  (合作)
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影响因子:5.294 (2012)

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