Persistent infection by HCV and EBV in peripheral blood mononuclear cells and risk of non-Hodgkin's lymphoma
作者: Lorenzo RichiardiLaura De MarcoAnna Gillio-TosFranco MerlettiValentina FianoDomenico PalliGiovanna MasalaClaudia AgnoliGiovanna TagliabueSalvatore PanicoAmalia MattielloRosario TuminoGraziella FrascaPaolo VineisCarlotta Sacerdote
作者单位: 1Cancer Epidemiology Unit, CeRMS and CPO-Piemonte, University of Turin, Via Santena 7, 10129 Turin, Italy
2Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy
3Department of Preventive & Predictive Medicine, Nutritional Epidemiology Unit, Fondazione IRCSS Istituto Nazionale dei Tumori, Milan, Italy
4Unit of Cancer Register, Fondazione IRCSS Istituto Nazionale dei Tumori, Milan, Italy
5Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
6Cancer Registry, Azienda Ospedaliera Civile M. P. Arezzo, Ragusa, Italy
7Department of Epidemiology and Public Health, MRC Centre for Environment and Health, Imperial College London, London, UK
刊名: Cancer Epidemiology, 2010, Vol.34 (6), pp.709-712
来源数据库: Elsevier Journal
DOI: 10.1016/j.canep.2010.07.014
关键词: Non-Hodgkin's lymphomaCase–control studyHepatitis C virus
原始语种摘要: Abstract(#br)Hepatitis C virus (HCV) and Epstein–Barr virus (EBV) have been repeatedly associated with risk of non-Hodgkin's lymphoma (NHL) in studies focusing on serological evidence of infection. We investigated NHL risk in association with detection of HCV-RNA or EBV-DNA in the peripheral blood mononuclear cells (PBMC). The study involved 91 NHL cases and 182 controls nested in the Italian branch of the EPIC (European Prospective Investigation of Cancer and nutrition) cohort, which obtained blood samples from 47,749 healthy volunteers between 1993 and 1998 in 5 Italian cities. NHL cases were identified until June 2005 through linkage with records of the Cancer, Mortality, and Hospital Discharge Registries. For all study subjects, we performed viral genome analyses on DNA and RNA...
全文获取路径: Elsevier  (合作)
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影响因子:2.232 (2012)

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关键词翻译
关键词翻译
  • lymphoma 淋巴瘤
  • EBV Extended Binary Vectors
  • infection 感染
  • peripheral 周边的
  • blood 血液
  • controls 控制机构
  • predictor 预示
  • mononuclear 单核的
  • cells 麻风细胞
  • serological 血清学的