Behavioral effects of photothrombotic ischemic cortical injury in aged rats treated with the sedative-hypnotic GABAergic drug zopiclone
作者: Chuan-sheng ZhaoKirsi PuurunenTimothy SchallertJuhani SiveniusJukka Jolkkonen
作者单位: 1Department of Neuroscience and Neurology, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland
2Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Austin, TX, USA
3Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA
4Department of Neurology, University Hospital of Kuopio and Brain Research and Rehabilitation Center Neuron, Kuopio, Finland
刊名: Behavioural Brain Research, 2004, Vol.160 (2), pp.260-266
来源数据库: Elsevier Journal
DOI: 10.1016/j.bbr.2004.12.007
关键词: AgingCerebral ischemiaFunctional recoveryGABARats
原始语种摘要: Abstract(#br)Sedative-hypnotic drugs commonly used in the elderly may affect functional recovery following cerebrovascular events. Previous research has shown that prolonged exposure to diazepam can interfere with recovery of function and exaggerate tissue loss after brain injury. The present study evaluated the effect of zopiclone, a widely used hypnotic drug, on functional and histological outcome after cortical photothrombosis in aged rats, which might be particularly vulnerable to brain insults and inhibitory sedative-hypnotic drugs. Aged Wistar rats were treated with zopiclone at a dose of 3mg/kg (i.p., once a day) beginning 4 days before ischemia induction and continuing for 23 days. Sensorimotor recovery was assessed by a new ledged beam-walking test and spatial...
全文获取路径: Elsevier  (合作)
影响因子:3.327 (2012)

  • zopiclone 佐匹克隆
  • hypnotic 催眠剂
  • sedative 镇静剂
  • ischemic 福尔克曼氏麻痹
  • treated 加工的
  • washout 冲蚀
  • cortical 皮层的
  • diazepam 安定
  • impaired 受损
  • vulnerable 要害