A systematic evaluation of poloxamers as tablet lubricants
作者: Jiangnan DunFrederick Osei-YeboahPierre BoulasYiqing LinChangquan Calvin Sun
作者单位: 1Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, 9-127B Weaver-Densford Hall, 308 Harvard Street S.E., Minneapolis, MN 55455, United States
2Product and Technical Development, Biogen, 225 Binney St., Cambridge, MA 02142, United States
刊名: International Journal of Pharmaceutics, 2020, Vol.576
来源数据库: Elsevier Journal
DOI: 10.1016/j.ijpharm.2019.118994
关键词: PoloxamerMagnesium stearateLubricationTabletabilityDissolutionFormulation
英文摘要: Abstract(#br)Lubricants are important for both preserving the tooling of high-speed tablet presses and attaining quality tablets. Magnesium stearate (MgSt) is most commonly used due to its superior lubrication efficiency; however, it can lead to negative effects on tabletability and dissolution. In this study, we have systematically evaluated two poloxamers, P188 and P407, for their suitability as alternative tablet lubricants. For two excipients with different mechanical properties, i.e., microcrystalline cellulose and lactose, both poloxamers exhibit acceptable lubrication efficiency without negatively impacting tabletability. Compared to 1% MgSt, the performance of 2% of both poloxamers in an experimental tablet formulation of ritonavir led to better lubrication, higher tabletability,...
全文获取路径: Elsevier  (合作)
影响因子:3.458 (2012)

  • tablet 药片
  • stearate 硬脂酸盐
  • systematic 有系统的
  • evaluation 评价