Particulate matter (PM10) induces cardiovascular developmental toxicity in zebrafish embryos and larvae via the ERS, Nrf2 and Wnt pathways
颗粒物( PM10 )通过ERS、Nrf2和Wnt通路诱导斑马鱼胚胎和幼虫心血管发育毒性
作者: Juan CenZhi-li JiaCheng-yue ZhuXue-fang WangFeng ZhangWei-yun ChenKe-chun LiuSai-yu LiYun Zhang
作者单位: 1Key Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng, Henan Province, PR China
2Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, Shandong Province, PR China
3Jigang Hospital, Jinan, Shandong Province, PR China
4College of Pharmacy, Henan University, Kaifeng, Henan Province, PR China
5Shandong Analysis and Test Center, Jinan, Shandong Province, PR China
刊名: Chemosphere, 2020, Vol.250
来源数据库: Elsevier Journal
DOI: 10.1016/j.chemosphere.2020.126288
关键词: PM10Cardiovascular toxicityERSNrf2Wnt
英文摘要: Abstract(#br)Particulate matter (PM10) is one of the most important indicators of the pollution that characterizes air quality. Epidemiological studies have shown that PM10 can cause cardiovascular-related diseases in the population. And, we studied the developmental toxicity of PM10 and the underlying mechanism of its effects on the cardiovascular system of zebrafish embryo/larva. Changes in cardiac morphology, sinus venosus and bulbus arteriosus (SV-BA) distance, heart rate, vascular subintestinalis, blood flow, returned blood volume, and reactive oxygen species (ROS) level were measured, and changes in the expression levels of certain genes were assessed via RT-PCR. The results showed that PM10 caused a significant increase in pericardial sac area and SV-BA distance, a decrease in...
全文获取路径: Elsevier  (合作)
影响因子:3.137 (2012)

  • Electronic Register Sender 物质
  • larvae 幼虫
  • developmental 试验性的
  • toxicity 毒性
  • matter 物质
  • ERS 物质
  • cardiovascular 心血管的