Antiproliferative effects of pinostrobin and 5,6-dehydrokavain isolated from leaves of Alpinia zerumbet
作者: Walter A. Roman JuniorDenise B. GomesBarbara ZanchetAmanda P. SchönellKriptsan A.P. DielThais P. BanzatoAna L.T.G. RuizJoão E. CarvalhoAngelita NeppelAndersson BarisonCid Aimbiré M. Santos
作者单位: 1Programa de Pós-graduação em Ciências da Saúde, Universidade Comunitária da Região de Chapecó, Chapecó, SC, Brazil
2Grupo de Pesquisa em Fitoquímica e Farmacologia de Produtos Naturais, Universidade Comunitária da Região de Chapecó, Chapecó, SC, Brazil
3Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas, Divisão de Farmacologia e Toxicologia, Universidade Estadual de Campinas, Campinas, SP, Brazil
4Faculdade de Ciências Farmacêuticas, Universidade Estadual de Campinas, Campinas, SP, Brazil
5Departamento de Química, Universidade Federal do Paraná, Curitiba, PR, Brazil
6Laboratório de Farmacognosia, Departamento de Farmácia, Universidade Federal do Paraná, Curitiba, PR, Brazil
刊名: Revista Brasileira de Farmacognosia, 2017
来源数据库: Elsevier Journal
DOI: 10.1016/j.bjp.2017.05.007
关键词: Medicinal plantsAntiproliferative effects56-DehydrokavainPinostrobinAntitumor agents
原始语种摘要: Abstract(#br)Natural products are a major source of drugs for the treatment of cancer. The species Alpinia zerumbet (Pers.) B.L. Burtt & R.M. Sm, Zingiberaceae, is widely distributed in Brazil where it is known as “colônia”. The leaves are commonly used in the treatment of hypertension and dyspepsia, however, the effects of A. zerumbet extracts and isolated substances on human cancer cells remain to be elucidated. This study was designed to identify the chemical constituents of hydroalcoholic and dichloromethane extracts from A. zerumbet leaves and to investigate their in vitro antiproliferative activity. The isolated phytochemicals included kaempferol, dihydro-5,6-dehydrokavain, 5,6-dehydrokavain, and pinostrobin. The hydroalcoholic extract inhibited cellular proliferation only at high...
全文获取路径: Elsevier  (合作)
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关键词翻译
关键词翻译
  • pinostrobin 基黄烷酮
  • kaempferol 7三羟黄酮醇
  • extracts 摘记
  • isolated 隔离
  • against 反对
  • moderate 适当的
  • leukemia 白血病
  • potent 强大的
  • effect 效应
  • cytostatic 抑制细胞生长的