Association between 5-hydroxytryptamine 2A receptor gene polymorphism and postoperative analgesic requirements after major abdominal surgery
作者: Jun AokiMasakazu HayashidaMegumi TagamiMakoto NagashimaKen-ichi FukudaDaisuke NishizawaYasukazu OgaiShinya KasaiKazutaka IkedaKazuhiko Iwahashi
作者单位: 1Laboratory of Neurophysiology, Graduate School of Environmental Health Sciences, Azabu University, Japan
2Division of Psychobiology, Tokyo Institute of Psychiatry, Japan
3Department of Neuropsychiatry, Tokyo Women's Medical University, Japan
4Department of Anesthesiology, Saitama Medical University International Medical Center, Japan
5Department of Anesthesiology, Toho University Sakura Medical Center, Japan
6Department of Surgery, Toho University Sakura Medical Center, Japan
7Department of Dental Anesthesia/Orofacial Pain Center, Suidoubashi Hospital, Tokyo Dental College, Japan
8Health Administration Center, Azabu University, Japan
刊名: Neuroscience Letters, 2010, Vol.479 (1), pp.40-43
来源数据库: Elsevier Journal
DOI: 10.1016/j.neulet.2010.05.024
关键词: 5-HT2A receptor gene polymorphismPostoperative painAnalgesia
原始语种摘要: Abstract(#br)Although the serotonin (5-hydroxytryptamine (5-HT)) 2A receptor has been reported to be associated with pain, no relationship has been found between single nucleotide polymorphisms in the 5-HT2A receptor gene and analgesic requirements. To clarify the mechanism of individual differences in analgesic requirements, we investigated the relationship between the 5-HT2A 102T/C gene polymorphism and analgesic requirements in 135 patients who underwent major open abdominal surgery and were managed with continuous epidural analgesia with opioids after surgery. Genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism. We found that the 102T/C polymorphism had significant main effects with regard to analgesic requirements. In addition,...
全文获取路径: Elsevier  (合作)
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影响因子:2.026 (2012)

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关键词翻译
关键词翻译
  • analgesic 镇痛药
  • postoperative 手术后的
  • receptor 接受体
  • polymorphism 多晶形
  • analgesia 痛觉缺失
  • epidural 硬膜外的
  • abdominal 腹部的
  • major 知的
  • between 在中间
  • serotonin 血清素