Effects of long non-coding RNA (lncRNA) cancer susceptibility candidate 2c (CASC2c) on proliferation, metastasis and drug resistance of non-small cell lung cancer (NSCLC) cells through ERK1/2 and β-catenin signaling pathways
作者: Lingfei TongWenming Wu
作者单位: 1Department of Pharmacy, Jiangxi Provincial People’s Hospital, Aiguo Road 152, Donghu, Nanchang, Jiangxi, People’s Republic of China
刊名: Pathology - Research and Practice, 2019, Vol.215 (9)
来源数据库: Elsevier Journal
DOI: 10.1016/j.prp.2019.152522
关键词: Non-small cell lung cancer (NSCLC)Long non-coding RNA cancer susceptibility candidate 2c (lncRNA CASC2c)ERK1/2Β-cateninDrug resistance
原始语种摘要: Abstract(#br)Objectives(#br)This study was aimed to investigate the effects of long non-coding RNA (lncRNA) cancer susceptibility candidate 2c (CASC2c) on the proliferation, metastasis and drug resistance of non-small cell lung cancer (NSCLC) cells.(#br)Methods(#br)The expression of CASC2c in NSCLC tissues and cell lines was detected by real-time fluorescence quantitative PCR (RT-qPCR). MTT and Transwell assay were used to determine the proliferation and migration of NSCLC cells in the experimental group and the control group respectively. The drug sensitivity test was used to confirm whether increasing the CASC2c expression level could reverse the resistance of NSCLC cells to the chemotherapy drug cisplatin. The effects of CASC2c on the expression levels of p-ERK1/2 and β-catenin were...
全文获取路径: Elsevier  (合作)
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影响因子:1.213 (2012)

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关键词翻译
关键词翻译
  • cells 麻风细胞
  • susceptibility 磁化率
  • metastasis 同质蜕变
  • cancer 癌症
  • candidate 选择物
  • proliferation 增生
  • coding 编码
  • chemotherapy 化学疗法
  • cisplatin 顺氯氨铂
  • expressed 榨出的