1 H NMR-based metabonomics approach in a rat model of acute liver injury and regeneration induced by CCl 4 administration
作者: Athina ZiraSarantos KostidisStamatios TheocharisFragiska SigalaSøren Balling EngelsenIoanna AndreadouEmmanuel Mikros
作者单位: 1Department of Pharmaceutical Chemistry, School of Pharmacy, University of Athens, Panepistimioupolis Zografou, 15771 Athens, Greece
2Department of Forensic Medicine and Toxicology, Medical School, University of Athens, Mikras Asias str., 11527 Athens, Greece
3First Department of Propedeutic Surgery, Medical School, University of Athens, Vassilis Sophias 114, 11527 Athens, Greece
4Quality & Technology, Department of Food Science, Faculty of Science, University of Copenhagen Rolighedsvej 30, DK-1958 Frederiksberg C, Denmark
刊名: Toxicology, 2013, Vol.303 , pp.115-124
来源数据库: Elsevier Journal
DOI: 10.1016/j.tox.2012.10.015
关键词: Carbon tetrachlorideLiverAcute injuryNuclear magnetic resonance spectroscopyMetabonomicsPrincipal component analysis
原始语种摘要: Abstract(#br)The administration of carbon tetrachloride (CCl 4 ) has been established as a model of toxin-induced acute and chronic liver injury. In the present study, we investigate the progression of the biochemical response to acute CCl 4 -induced liver injury, capturing metabolic variations during both toxic insult and regeneration using NMR-based metabonomic analysis of liver tissue and plasma.(#br)A single dose of CCl 4 (1mL/kg BW) was intraperitoneally administered to male Wister rats sacrificed every 12h up to 72h post treatment, while healthy animals served as controls. Acquired 1 H NMR spectra of liver tissue extracts and plasma samples were explored with multivariate analysis and the resulted models were correlated with...
全文获取路径: Elsevier  (合作)
影响因子:4.017 (2012)

  • liver 
  • induced 感应的
  • injury 损害
  • regenerative 再生放大
  • administration 管理
  • tetrachloride 四氯化物
  • acute 急尖的
  • biochemical 生物化学的
  • insult 欺侮
  • toxic 有毒的