Simultaneous exploration of nutrients and pollutants in human milk and their impact on preterm infant growth: An integrative cross-platform approach
作者: German Cano-SanchoMarie-Cécile Alexandre-GouabauThomas MoyonAnne-Lise RoyerYann GuittonHélène BillardDominique DarmaunJean-Christophe RozéClair-Yves BoquienBruno Le BizecJean-Philippe Antignac
作者单位: 1LABERCA, Oniris, INRA, 44307, Nantes, France
2Nantes Université, INRA, UMR1280, Physiopathologie des Adaptations Nutritionnelles, Centre de Recherche en Nutrition Humaine Ouest (CRNH-Ouest), Institut des Maladies de L'appareil Digestif (IMAD), F-44000, Nantes, France
3CHU, Centre Hospitalo-Universitaire Hôtel-Dieu, Nantes, France
4EMBA, European Milk Bank Association, Milano, Italy
刊名: Environmental Research, 2020, Vol.182
来源数据库: Elsevier Journal
DOI: 10.1016/j.envres.2019.109018
关键词: ExposomePersistent pollutantsBreast milkPreterm infantsBiomarkersNutrientsRisk-benefit assessment
英文摘要: Abstract(#br)Early nutritional management including fortified human breastmilk is currently recommended to fulfil the energy demands and counterbalance risks associated to preterm birth. However, little is known about the potential adverse effects of exposure to persistent organic pollutants (POPs) carried in human milk on preterm infant growth. We conducted a pilot study proving the application of an integrative analytical approach based on mass spectrometry (MS) coupled to advanced statistical models, favouring the comprehensive molecular profiling to support the identification of multiple biomarkers. We applied this workflow in the frame of a preterm infants’ cohort to explore environmental determinants of growth. The combination of high resolution gas and liquid chromatography MS...
全文获取路径: Elsevier  (合作)
影响因子:3.238 (2012)

  • platform 台地
  • growth 生长
  • human 人的
  • exploration 勘探
  • integrative 综合
  • impact 冲击碰撞
  • cross 十字
  • infant 幼儿
  • approach 
  • their 他们的