Cerebral activation in children and adolescents with obsessive–compulsive disorder before and after treatment: A functional MRI study
作者: Luisa LázaroXavier CaldúCarme JunquéNúria BargallóSusana AndrésAstrid MorerJosefina Castro-Fornieles
作者单位: 1Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clínic Universitari of Barcelona, Spain
2IDIBAPS (Institut d’Investigacions Biomèdiques August Pi I Sunyer), Spain
3Department of Psychiatry and Clinical Psychobiology, Health Sciences Division, University of Barcelona, Spain
4Image Diagnostic Center, Hospital Clínic Universitari of Barcelona, Spain
刊名: Journal of Psychiatric Research, 2007, Vol.42 (13), pp.1051-1059
来源数据库: Elsevier Journal
DOI: 10.1016/j.jpsychires.2007.12.007
关键词: Obsessive–compulsive disorderChild and adolescentsFunctional MRISerial reaction time taskPharmacological therapyFluoxetine
英文摘要: Abstract(#br)Background(#br)Structural and functional fronto-striatal abnormalities are involved in the pathophysiology of obsessive–compulsive disorder (OCD). The aims of the present study were: (a) to investigate possible regional brain dysfunction in premotor cortico-striatal activity in drug-naïve children and adolescents with OCD; (b) to correlate brain activation with severity of obsessive–compulsive symptomatology; and (c) to detect possible changes in brain activity after pharmacological treatment.(#br)Method(#br)Twelve children and adolescents (age range 7–18 years; seven male, five female) with DSM-IV obsessive–compulsive disorder and twelve healthy subjects matched for age, sex and intellectual level were studied. Functional magnetic resonance imaging data were obtained during...
全文获取路径: Elsevier  (合作)
影响因子:4.066 (2012)

  • compulsive 强制的
  • disorder 无序
  • children 子女
  • functional 功能的
  • MRI Machine-Readable Information
  • activation 活化
  • reaction 反酌
  • after 在之后
  • treatment 处理
  • therapy 治疗