Carnosol from Lepechinia mutica and tiliroside from Vallea stipularis : Two promising inhibitors of BuChE
作者: Jorge RamírezAlírica I. SuarezNicole BecChabaco ArmijosGianluca GilardoniChristian LarroqueGiovanni Vidari
作者单位: 1Departamento de Química y Ciencias Exactas, Universidad Técnica Particular de Loja, Calle Loja, Ecuador
2Dipartimento di Chimica, Centro di Studio in Etnobiofarmacia e Medicine Complementari, University of Pavia, Pavia, Italy
3Facultad de Farmacia, Universidad Central de Venezuela, Caracas, Venezuela
4Institut de Recherche en Cancérologie de Montpellier, Institut National de la Santé et de la Recherche Médicale U1194, Université de Montpellier, Institut Régional du Cancer de Montpellier, Montpellier, France
刊名: Revista Brasileira de Farmacognosia, 2018
来源数据库: Elsevier Journal
DOI: 10.1016/j.bjp.2018.06.003
关键词: EcuadorCarnosolTilirosideBuChE inhibitory activityEnzymatic studiesAnticholinesterase screening
原始语种摘要: Abstract(#br)Lepechinia mutica (Benth.) Epling, Lamiaceae, and Vallea stipularis L.f., Elaeocarpaceae, are the object of the present study. These plants are endemic to the Andean region and have attracted our attention on the basis of interesting results obtained in a preliminary anticholinesterase screening. Actually, carnosol and tiliroside, isolated from L. mutica and V. stipularis , respectively, have shown a promising selective inhibitory activity against butyrylcholinesterase. Specifically, the anti-butyrylcholinesterase activity of carnosol was 5.15μM and that of tiliroside was 52.9μM, compared to 8.568±0.570μM of the positive control Donepezil. Carnosol and tiliroside were purified...
全文获取路径: Elsevier  (合作)
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关键词翻译
关键词翻译
  • promising 前提
  • endemic 地方病
  • Ecuador 厄瓜多尔
  • carnosol 鼠尾草酚
  • screening 筛分
  • activity 活度
  • purified 净化的
  • acetate 醋酸盐
  • region 地域
  • inhibitory 禁止的