Effects of lecithin-based nanoemulsions on skin: Short-time cytotoxicity MTT and BrdU studies, skin penetration of surfactants and additives and the delivery of curcumin
作者: Claudia VaterVictoria HlawatyPatricia WerdenitsMałgorzata Anna CichońVictoria KlangAdelheid Elbe-BürgerMichael WirthClaudia Valenta
作者单位: 1University of Vienna, Department of Pharmaceutical Technology and Biopharmaceutics, Althanstraße 14, 1090 Vienna, Austria
2University of Vienna, Research Platform ‘Characterisation of Drug Delivery Systems on Skin and Investigation of Involved Mechanisms’, Althanstraße 14, 1090 Vienna, Austria
3Medical University of Vienna, Department of Dermatology, Währinger Gürtel 18-20, 1090 Vienna, Austria
刊名: International Journal of Pharmaceutics, 2020, Vol.580
来源数据库: Elsevier Journal
DOI: 10.1016/j.ijpharm.2020.119209
关键词: CurcuminNanoemulsionsLecithinPhospholipidsSurfactantsCytotoxicityATR-FTIRTape strippingSkin penetrationBrdU-assayMTT-assay
英文摘要: Abstract(#br)Surfactants are important ingredients in pharmaceutical and cosmetic formulations, as in creams, shampoos or shower gels. As conventional emulsifiers such as sodium dodecyl sulfate (SDS) have fallen into disrepute due to their skin irritation potential, the naturally occurring lecithins are being investigated as a potential alternative. Thus, lecithin-based nanoemulsions with and without the drug curcumin, known for its wound healing properties, were produced and characterised in terms of their particle size, polydispersity index (PDI) and zeta potential and compared to SDS-based formulations. In vitro toxicity of the produced blank nanoemulsions was assessed with primary human keratinocytes and fibroblasts using two different cell viability assays (BrdU and EZ4U). Further,...
全文获取路径: Elsevier  (合作)
影响因子:3.458 (2012)

  • penetration 穿透
  • stripping 剥土探矿
  • curcumin 姜黄色素
  • lecithin 卵磷脂
  • additives 附加剂
  • FTIR Flight Test Instrumentation Requirements
  • Skin 皮肤
  • delivery 移交
  • cytotoxicity 细胞毒性
  • based 基于