Cross-sectional analysis of adhesion in individuals with sickle cell disease using a standardized whole blood adhesion bioassay to VCAM-1
作者: Jennell WhiteMoira LancelotXiufeng GaoBettina Joi McGrawCarl TabbPatrick Hines
作者单位: 1Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI, United States of America
2Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, United States of America
3Emory Univeristy, Atlanta, GA, United States of America
4Children's National Health System, Washington, DC, United States of America
5Children's Hospital of Michigan, Detroit, MI, United States of America
6Division of Critical Care Medicine, Detroit, MI, United States of America
7Department of Physiology, Wayne State University School of Medicine, Detroit, MI, United States of America
刊名: Blood Cells, Molecules and Diseases, 2020, Vol.81
来源数据库: Elsevier Journal
DOI: 10.1016/j.bcmd.2019.102397
关键词: VLA-4VCAM-1AdhesionSickle cell diseaseMicrofluidics
英文摘要: Abstract(#br)Sickle cell disease (SCD) is characterized by frequent and unpredictable vaso-occlusive episodes (VOEs) that lead to severe pain, organ damage, and early death. Lack of reliable biomarkers that objectively define VOEs remains a critical barrier to improving the care for SCD patients. VOEs result from a complex interplay of cell-cell interactions that promote micro-vascular occlusion. Earlier studies demonstrated that sickle erythrocytes are more adherent than non-sickle erythrocytes and established a direct link between adhesion and frequency of VOEs. We developed a standardized, flow-based adhesion bioassay to assess the adhesive properties of SCD blood samples. The current study provides a cross-sectional analysis of steady state adhesion in SCD patients presenting at...
全文获取路径: Elsevier  (合作)
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影响因子:2.259 (2012)

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关键词翻译
关键词翻译
  • adhesion 粘附
  • whole 全部的
  • sickle 切割器镰刀
  • sectional 部分的
  • Sickle 轩辕八至十三
  • VLA Very-Large Array
  • standardized 用标准校验(了)的标准化(了)的
  • bioassay 生物测定
  • blood 血液
  • analysis 分析