The infarction zone rather than the noninfarcted remodeling zone overexpresses angiotensin II receptor type 1 and is the main source of ventricular atrial natriuretic peptide
作者: Kun ZhangStephan WiedemannMartin DschietzigMelissa M. CremersAntje AugsteinDavid M. PoitzSilvio QuickChristian PflueckeFrank R. HeinzelBurkert PieskeVolker AdamsAxel LinkeRuth H. StrasserFelix M. Heidrich
作者单位: 1Department of Internal Medicine and Cardiology, Charité – Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany
2Berlin Institute of Health (BIH), Berlin, Germany
3Helios Klinikum Pirna, Department of Internal Medicine and Cardiology, Pirna, Germany
4Department of Internal Medicine and Cardiology, Herzzentrum Dresden at Technische Universität Dresden, Dresden, Germany
5DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany
6Institute for Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, Dresden, Germany
7Technische Universität Dresden, Medical Faculty, Dresden, Germany
刊名: Cardiovascular Pathology, 2020, Vol.44
来源数据库: Elsevier Journal
DOI: 10.1016/j.carpath.2019.107160
关键词: Myocardial infarctionCalciumAngiotensin IIInositol 145-trisphosphateChromogranin BNuclear factor kappa B
英文摘要: Abstract(#br)Chromogranin B and inositol 1,4,5-trisphosphate-associated calcium signaling leading to increased natriuretic peptide production has been described in cardiac hypertrophy. Here, we performed left anterior descending coronary artery ligation in rats as a model for systolic heart failure and examined protein and gene expression clusters in the infarcted and noninfarcted myocardium and moreover under treatment with metoprolol.(#br)We found that atrial natriuretic peptide gene transcription was significantly more elevated in the infarcted compared with the noninfarcted myocardium. Chromogranin B, which facilitates calcium release from internal stores through the inositol 1,4,5-trisphosphate receptor, was upregulated in both areas. Interestingly, angiotensin II receptor type 1...
全文获取路径: Elsevier  (合作)
影响因子:2.352 (2012)

  • natriuretic 促尿钠排泄的
  • atrial 围鳃的
  • infarction 梗塞
  • angiotensin 血管紧张肽
  • remodeling 重新塑造
  • ventricular 室的
  • peptide 
  • receptor 接受体
  • rather 宁愿
  • source