In vivo anti-hyperuricemic activity of sesquiterpene lactones from Lychnophora species
作者: Ana Catharina Fernandes Pereira Ferreira BernardesGrazielle Brandão CoelhoMarcela Carolina de Paula Michel AraújoDênia Antunes Saúde-Guimarães
作者单位: 1Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil
刊名: Revista Brasileira de Farmacognosia, 2019, Vol.29 (2), pp.241-245
来源数据库: Elsevier Journal
DOI: 10.1016/j.bjp.2018.12.008
关键词: Sesquiterpene lactonesHyperuricemiaXanthine oxidaseUricosuric effectGout
原始语种摘要: Abstract(#br)Hyperuricemia is the main cause of gout, an inflammation induced by uric acid deposition in joints. Drugs available present side effects, so there is a need for new treatment alternatives. Lychnophora species are used in folk medicine to treat inflammation, rheumatism and muscle pain. Goyazensolide (10mg/kg), eremantholide C (25mg/kg) and lychnopholide (25mg/kg), sesquiterpene lactones isolated from Lychnophora species were previously studied and showed anti-hyperuricemic effects in mice. However, the mechanisms of this effect were not elucidated. The methodology of this study consisted in treatment of hyperuricemic-induced rats, and comparison between control groups, clinically used anti-hyperuricemic drugs and...
全文获取路径: Elsevier  (合作)

  • sesquiterpene 倍半萜烯
  • uricosuric 促尿酸排泄药
  • hyperuricemia 血尿酸过多
  • effect 效应
  • activity 活度
  • inflammation 炎症
  • oxidase 氧化酶
  • induced 感应的
  • xanthine 黄质
  • inhibition 抑制