Molecular bottlebrush as a unimolecular vehicle with tunable shape for photothermal cancer therapy
作者: Huaan LiHong LiuTianqi NieYi ChenZhiyong WangHuahua HuangLixin LiuYongming Chen
作者单位: 1School of Materials Science and Engineering, Center for Functional Biomaterials, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Sun Yat-sen University, Guangzhou 510275, China
刊名: Biomaterials, 2018, Vol.178 , pp.620-629
来源数据库: Elsevier Journal
DOI: 10.1016/j.biomaterials.2018.03.032
关键词: Drug deliveryMolecular bottlebrushPhotothermal therapyUnimolecular micelle
英文摘要: Abstract(#br)Morphology of delivery nanovehicle plays a significant role in bioavailability of drug. Molecular bottlebrush (MBB)-based unimolecular micelle, with tunable morphologies including sphere, rod, and worm, offers a new aspect to uncover the relationship between morphology and bio-behaviors. In this study, a series of MBB as unimolecular micelle with core-shell structures were tailor-made through controlled/living polymerization and click chemistry, and served as carriers of IR780 photothermal agent. With an excellent IR780 loading content of up to ca . 25%, these molecular nanovehicles still maintained their molecular morphologies and did not aggregate in cell culture medium. Among three MBB, the rodlike one exhibited best performance in cell uptake in the 2D and also in...
全文获取路径: Elsevier  (合作)
影响因子:7.604 (2012)

  • bottlebrush 瓶刷形分枝
  • tunable 可(协)调
  • unimolecular 单分子的
  • vehicle 
  • shape 形状
  • cancer 癌症
  • therapy 治疗