Investigation of the lipophilic behaviour of some thiazolidinediones
作者: Costas GiaginisStamatios TheocharisAnna Tsantili-Kakoulidou
作者单位: 1Department of Pharmaceutical Chemistry, School of Pharmacy, University of Athens, Panepistimiopolis, Zografou, Athens 157 71, Greece
2Department of Forensic Medicine and Toxicology, Medical School, University of Athens, 75 Mikras Asias Street, Athens 11527, Greece
刊名: Journal of Chromatography B, 2007, Vol.857 (2), pp.181-187
来源数据库: Elsevier Journal
DOI: 10.1016/j.jchromb.2007.07.013
关键词: ThiazolidinedionesPPAR-γ ligandsLipophilicityn -Octanol/water partitioningRP-HPLCIAM chromatography
原始语种摘要: Abstract(#br)Various lipophilicity aspects of five well-known PPAR-γ ligands, belonging to the thiazolidinedione (TZD) class, ciglitazone (CSZ), troglitazone (TGZ), netoglitazone (NGZ) and the ampholytic pioglitazone (PGZ) and rosiglitazone (RGZ), have been explored. The compounds were found to be highly lipophilic as assessed by direct octanol–water partitioning experiments and further confirmed by reversed phase HPLC measurements under different conditions. Immobilised artificial membrane (IAM) chromatographic indices were also determined as an alternative expression of lipophilicity. They were found to show less diversity forming two clusters. Experimental log D /log P values were compared to those predicted by three widely used calculation...
全文获取路径: Elsevier  (合作)
影响因子:2.487 (2012)

  • lipophilic 亲油性
  • reversed 倒转的
  • partitioning 分块
  • binding 装订
  • octanol 辛醇
  • broad 宽的
  • conditions 条件式
  • satisfactory 满意的
  • values 价值观
  • biological 生物学的