KLF2 induces the senescence of pancreatic cancer cells by cooperating with FOXO4 to upregulate p21
作者: Dai YuediLiu HoubaoLu PinxiangWang HuiTao MinZhang Dexiang
作者单位: 1Department of Medical Oncology, The First Affiliated Hospital of Soochow University, Soochow, 215006, China
2Department of Medical Oncology, Fudan University Shanghai Cancer Center, Minhang Branch, Shanghai, 200240, China
3General Surgery Department, Zhongshan Hospital, General Surgery Institute, Fudan University, 180 Fenglin Rd., Shanghai, 200032, China
4General Surgery Department, Zhongshan-Xuhui Hospital Affiliated to Fudan University, Shanghai, 200031, China
刊名: Experimental Cell Research, 2020, Vol.388 (1)
来源数据库: Elsevier Journal
DOI: 10.1016/j.yexcr.2019.111784
关键词: Pancreatic cancerSenescenceKLF2FOXO4
英文摘要: Abstract(#br)Pancreatic cancer is one of the most common malignancies in the world. Senescence is frequently observed in the progression of pancreatic cancer. In a previous study, we showed that KLF2 inhibited the growth and migration of pancreatic cancer. However, the mechanisms are not fully understood. In this study, we showed that overexpression of KLF2 induced the senescence of pancreatic cancer cells and inhibited tumorigenesis, and knockdown of KLF2 inhibited senescence and p21 expression. In the molecular mechanism study, KLF2 was found to interact with FOXO4 and cooperated with FOXO4 to induce the expression of p21. Downregulation of p21 and FOXO4 impaired the induction of senescence by KLF2. Overall, this study revealed the functions and mechanisms of KLF2 in senescence and...
全文获取路径: Elsevier  (合作)
影响因子:3.557 (2012)

  • pancreatic 胰的
  • cells 麻风细胞
  • senescence 衰老
  • cancer 癌症