Critical steps during the prilling process of molten lipids: Main stumbling blocks due to pharmaceutical excipient properties
作者: F. SéquierV. FaivreJ.-Y. LanneG. DasteM. RenouardS. Lesieur
作者单位: 1Université Paris-Saclay, CNRS, Institut Galien Paris Sud, 5 rue JB Clément, 92296 Châtenay-Malabry, France
2Sanofi Winthrop Industrie, 1 Rue de la Vierge, 33 565 Carbon Blanc Cedex, France
刊名: International Journal of Pharmaceutics, 2020, Vol.576
来源数据库: Elsevier Journal
DOI: 10.1016/j.ijpharm.2020.119036
关键词: PrillingLipidPolymorphismMonotropismSupercooling
英文摘要: Abstract(#br)Prilling by ultrasonic jet break-up is an efficient process to produce perfectly spherical microparticles homogeneous in size. However, the material properties could affect the manufacturability and the final product properties especially with lipid-based excipients which often exhibit complex structural properties. This work presents the characterisation of six lipid-based excipients differing by their melting point and polymorphic behaviour which were used to produce microspheres using a pilot-scale prilling equipment. The experimental results were compared to theoretical calculations, especially the droplet solidification time which is a key-parameter for this process. This work highlighted that monotropic polymorphism of excipients and supercooling effect have a...
全文获取路径: Elsevier  (合作)
影响因子:3.458 (2012)

  • excipient 赋形剂
  • prilling 金属小球
  • pharmaceutical 
  • process 过程
  • during 在的期间
  • molten 熔化的
  • steps 无扶手步梯
  • blocks 块状体
  • properties 道具
  • lipids 类脂