Clinical and pathological stage discordance among 433,514 breast cancer patients
作者: Jennifer K. PlichtaSamantha M. ThomasAmanda R. SergesketterRachel A. GreenupOluwadamilola M. FayanjuLaura H. RosenbergerNina TamirisaTerry HyslopE. Shelley Hwang
作者单位: 1Department of Surgery, Duke University Medical Center, Durham, NC, USA
2Duke Cancer Institute, Durham, NC, USA
3Department of Biostatistics & Bioinformatics, Duke University, Durham, NC, USA
刊名: The American Journal of Surgery, 2019, Vol.218 (4), pp.669-676
来源数据库: Elsevier Journal
DOI: 10.1016/j.amjsurg.2019.07.016
关键词: Breast cancer stagingClinical stagePathological stageStage discordance
原始语种摘要: Abstract(#br)Background(#br)We aim to determine clinical and pathological stage discordance rates and to evaluate factors associated with discordance.(#br)Methods(#br)Adults with clinical stages I-III breast cancer were identified from the National Cancer Data Base. Concordance was defined as cTN = pTN (discordance: cTN≠pTN). Multivariate logistic regression was used to identify factors associated with discordance.(#br)Results(#br)Comparing clinical and pathological stage, 23.1% were downstaged and 8.7% were upstaged. After adjustment, factors associated with downstaging (vs concordance) included grade 3 (OR 10.56, vs grade 1) and HER2-negative (OR 3.79). Factors associated with upstaging (vs concordance) were grade 3 (OR 10.56, vs grade 1), HER2-negative (OR 1.25), and lobular histology...
全文获取路径: Elsevier  (合作)
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影响因子:2.516 (2012)

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关键词翻译
关键词翻译
  • pathological 病理学的
  • discordance 不整合
  • breast 胸部
  • stage 
  • cancer 癌症
  • among 在当中