Stimuli-responsive charge-reversal nano drug delivery system: The promising targeted carriers for tumor therapy
作者: Zengjun FangShaobin PanPeng GaoHuagang ShengLingjun LiLei ShiYongqing ZhangXiaoqing Cai
作者单位: 1School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province 250355, PR China
2Department of Pharmacy, The Second Hospital of Shandong University, Jinan, Shandong Province 250033, PR China
刊名: International Journal of Pharmaceutics, 2020, Vol.575
来源数据库: Elsevier Journal
DOI: 10.1016/j.ijpharm.2019.118841
关键词: Stimuli-responsiveCharge-reversal nano drug delivery systemsTumor microenvironmentTargeted therapy
英文摘要: Abstract(#br)The stimuli-responsive charge-reversal nano drug delivery system (CRNDDS) for the treatment of tumors has attracted much attention as an effective drug delivery system. The charge-reversal nanocarriers are either uncharged or negatively charged under normal physiological environment; however, they acquire positive charged in tumor tissue microenvironment. The process of charge reversal from negative-to-positive results in not only quick drug release in acidic environment but also enhance the cellular uptake of drug through electrostatic absorptive endocytosis resulting in improvement of cancer therapeutic outcome. In this review, we discuss the recent advances in the study of charge-reversal nanocarriers that could control the distribution of drugs in response to specific...
全文获取路径: Elsevier  (合作)
影响因子:3.458 (2012)

  • reversal 倒转
  • targeted 对准目标的
  • responsive 承担责任
  • delivery 移交
  • therapy 治疗
  • tumor 肿胀
  • promising 前提
  • charge 电荷
  • system