Chemiluminescence chitosan hydrogels based on the luminol analog L-012 for highly sensitive detection of ROS
作者: Wancun ZhangLina HaoJinxin HuangLili XiaMengyuan CuiXianwei ZhangYueqing GuPeng Wang
作者单位: 1Children's Hospital Affiliated of Zhengzhou University, Zhengzhou, 450000, China
2Department of Pharmacy, Qilu Children's Hospital of Shandong University, Jinan, 250022, China
3Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, Nanjing, 210009, China
刊名: Talanta, 2019, Vol.201 , pp.455-459
来源数据库: Elsevier Journal
DOI: 10.1016/j.talanta.2019.04.051
关键词: ChemiluminescenceChitosan hydrogelsROSImaging
英文摘要: Abstract(#br)Chemiluminescence probes have been widely used in a very broad field including immunoassay or non-immunoassay diagnostic and monitoring techniques as well as biosensors. The luminol analog L012 as a chemiluminescence probe was applied in the detection of reactive oxygen species (ROS). However, the short chemiluminescence time of L012 limits its application in imaging in vivo. In this study, we developed chemiluminescence chitosan hydrogels L012-Cs-Co 2+ based on a slow-diffusion-controlled heterogeneous catalytic mechanism. The hydrogels can emit strong chemiluminescence in the presence of H 2 O 2 , which can be observed by naked eyes in the darkroom within 60 min. They also exhibited high sensitivity towards H 2 O 2 with the calculated detection limit of 8.7 × 10 −8 M. In...
全文获取路径: Elsevier  (合作)
影响因子:3.498 (2012)

  • luminol 鲁米诺
  • detection 探测
  • chitosan 壳聚糖
  • highly 高度地
  • based 基于
  • analog 相似体
  • sensitive 灵敏的
  • ROS Read Only Storage