Anti-inflammatory functions of the CDC25 phosphatase inhibitor BN82002 via targeting AKT2
作者: Han Gyung KimWoo Seok YangYo Han HongDae-Hyuk KweonJongsung LeeSunggyu KimJae Youl Cho
作者单位: 1Department of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, Republic of Korea
2Research and Business Foundation, Sungkyunkwan University, Suwon 16419, Republic of Korea
3Department of Biocosmetics, Sungkyunkwan University, Suwon 16419, Republic of Korea
刊名: Biochemical Pharmacology, 2019, Vol.164 , pp.216-227
来源数据库: Elsevier Journal
DOI: 10.1016/j.bcp.2019.04.007
关键词: Anti-inflammatory effectBN82002AKT2Inflammatory mediators
英文摘要: Abstract(#br)This study presents BN82002 as an anti-inflammatory drug candidate. It was found that BN82002 inhibited the production of nitric oxide (NO) and prostaglandin E 2 (PGE 2 ) in RAW 264.7 cells and peritoneal macrophages that were activated by toll-like receptor (TLR) 4 ligand, lipopolysaccharide (LPS). BN82002 dose-dependently down-regulated mRNA levels of nitric oxide synthase, tumor necrosis factor-α, and cyclooxygenase-2. The nuclear translocation of nuclear factor (NF)-κB (p65 and p50) was also blocked by BN82002 in RAW265.7 cells stimulated by LPS. According to reporter gene assay performed with NF-κB construct, BN82002 clearly reduced increased level of luciferase activity mediated by transcription factor NF-κB in LPS-treated RAW264.7 cells and in MyD88- and...
全文获取路径: Elsevier  (合作)
影响因子:4.576 (2012)

  • targeting 导向目标
  • inflammatory 激怒的
  • phosphatase 磷酸酶
  • effect 效应
  • CDC Call Directing Code
  • inhibitor 抑制剂