The importance of the relationship between mechanical analyses and rheometry of mucoadhesive thermoresponsive polymeric materials for biomedical applications
作者: Sabrina Barbosa De Souza FerreiraJéssica Bassi Da SilvaMariana Volpato JunqueiraFernanda Belincanta Borghi-PangoniRaquel Guttierres GomesMarcos Luciano Bruschi
作者单位: 1Postgraduate Program in Pharmaceutical Sciences, Laboratory of Research and Development of Drug Delivery Systems, Department of Pharmacy, State University of Maringá, Maringá, Paraná, Brazil
2Department of Food Engineering, State University of Maringá, Maringá, Paraná, Brazil
刊名: Journal of the Mechanical Behavior of Biomedical Materials, 2017, Vol.74 , pp.142-153
来源数据库: Elsevier Journal
DOI: 10.1016/j.jmbbm.2017.05.040
关键词: CarbomerMucoadhesionSoftness indexTexture profile analysisPluronic F127Rheology
原始语种摘要: Abstract(#br)Pluronic F127 ® was associated with a carbomer homopolymer type B, as a model polymer blend to evidence the information provided by rheological and mechanical analyses on the development of bioadhesive thermoresponsive systems. The mechanical analysis enabled to observe that 20% (w/w) Pluronic F127 ® -polymer blends were harder, more adhesive, more mucoadhesive, more compressive and less soft. In addition, continuous flow rheometry demonstrated that the systems were plastic with rheopexy (15%, w/w, Pluronic F127 ® ) or thixotropic (20%, w/w, Pluronic F127 ® ). Oscillatory rheometry exhibited the increase of temperature, and the polymeric concentration increases the elasticity of the formulations. Moreover, correlation index showed that softness and textural analysis can be...
全文获取路径: Elsevier  (合作)

  • polymeric 聚合的
  • rheometry 测流学
  • homopolymer 均聚物
  • mechanical 机械的
  • rheological 流变学的
  • biomedical 生物医学
  • interaction 相互酌
  • analysis 分析
  • importance 重要性
  • thixotropic 触变的