Weak acids as an alternative anti-microbial therapy
作者: Binu KundukadGayathri UdayakumarErin GrelaDhamanpreet KaurScott A. RiceStaffan KjellebergPatrick S. Doyle
作者单位: 1BioSystems and Micromechanics (BioSyM) IRG, Singapore MIT Alliance for Research and Technology (SMART), Singapore
2School of Life and Physical Sciences, PSB academy, La Trobe University, Australia
3Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA
4Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA, USA
5Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore
6School of Biological Sciences, Nanyang Technological University, Singapore
7The ithree Institute, The University of Technology Sydney, Sydney, NSW, Australia
8Centre for Marine Bio-Innovation and School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW, Australia
9Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
刊名: Biofilm, 2020, Vol.2
来源数据库: Elsevier Journal
DOI: 10.1016/j.bioflm.2020.100019
关键词: BiofilmWeak acidsPHPKa
英文摘要: Abstract(#br)Weak acids such as acetic acid and N-acetyl cysteine (NAC) at pH less than their pKa can effectively eradicate biofilms due to their ability to penetrate the biofilm matrix and the cell membrane. However, the optimum conditions for their activity against drug resistant strains, and safety, need to be understood for their application to treat infections or to inactivate biofilms on hard surfaces. Here, we investigate the efficacy and optimum conditions at which weak acids can eradicate biofilms. We compared the efficacy of various mono and triprotic weak acids such as N-acetyl cysteine (NAC), acetic acid, formic acid and citric acid, in eradicating biofilms. We found that monoprotic weak acids/acid drugs can kill mucoid P. aeruginosa mucA biofilm bacteria provided the pH is...
全文获取路径: Elsevier  (合作)

  • alternative 可选择的
  • therapy 治疗
  • microbial 微生物的