Measurement of the enriched stable isotope 58 Fe in iron related disorders- comparison of INAA and MC-ICP-MS
作者: Tayser YagobAlbert van de WielPeter BodeAyse DemirBas van der WagtPetra KrystekBert Wolterbeek
作者单位: 1Delft University of Technology, Mekelweg 15, 2629 JB, Delft, the Netherlands
2Meander Medical Center, Maatweg 3, 3813 TZ, Amersfoort, the Netherlands
3VU University, De Boelelaan 1085, 1081 HV, Amsterdam, the Netherlands
刊名: Journal of Trace Elements in Medicine and Biology, 2019, Vol.53 , pp.77-83
来源数据库: Elsevier Journal
DOI: 10.1016/j.jtemb.2019.02.001
关键词: Iron stable isotopesIron related disordersINAAMC-ICP-MS
原始语种摘要: Abstract(#br)As a safer alternative for the use of radioactive tracers, the enriched stable 58 Fe isotope has been introduced in studies of iron metabolism. In this study this isotope is measured with instrumental neutron activation analysis (INAA) in blood samples of patients with iron related disorders and controls after oral ingestion of a 58 Fe containing pharmaceutical. Results were compared with those derived from MC-ICP-MS, applied on the same samples, and analytical and practical aspects of the two techniques were compared.(#br)Both techniques showed an increased absorption and incorporation in red blood cells of the 58 Fe isotope in iron deficient patients in contrast to the controls. In all individuals results of INAA measurements were in good agreement with those of MC-ICP-MS...
全文获取路径: Elsevier  (合作)

  • related 有关的
  • stable 稳定的
  • isotope 同位素
  • interfering 干涉
  • measurement 测量
  • alternative 可选择的
  • those 
  • incorporation 掺合
  • accessible 易接近的
  • facility 设备