Development and evaluation of well-tolerated and tumor-penetrating polymeric micelle-based dry powders for inhaled anti-cancer chemotherapy
作者: Rémi RosièreMatthias Van WoenselVéronique MathieuIngrid LangerThomas MathivetMarjorie VermeerschKarim AmighiNathalie Wauthoz
作者单位: 1Laboratoire de Pharmacie Galénique et de Biopharmacie, Faculté de Pharmacie Université libre de Bruxelles (ULB), Brussels, Belgium
2Research Group Experimental Neurosurgery and Neuroanatomy, Laboratory of Pediatric Immunology, KULeuven, Leuven, Belgium
3Laboratoire de Cancérologie et Toxicologie Expérimentale, Faculté de Pharmacie, ULB, Brussels, Belgium
4Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), ULB, Brussels, Belgium
5VIB Vesalius Research Center, KULeuven, Leuven, Belgium
6Center for Microscopy and Molecular Imaging (CMMI), Gosselies, Belgium
刊名: International Journal of Pharmaceutics, 2016, Vol.501 (1-2), pp.148-159
来源数据库: Elsevier Journal
DOI: 10.1016/j.ijpharm.2016.01.073
关键词: Lung cancerInhaled chemotherapyDry powder for inhalationFolateMicellePaclitaxel
原始语种摘要: Abstract(#br)Despite the direct access to the lung offered by the inhalation route, drug penetration into lung tumors could remain an important issue. In this study, folate-polyethylene glycol-hydrophobically-modified dextran (F-PEG-HMD) micelles were developed as an effective pulmonary drug delivery system to reach and penetrate lung tumors and cancer cells. The F-PEG-HMD micelles were able to enter HeLa and M109-HiFR, two folate receptor-expressing cancer cell lines, in vitro , and in vivo after administration by inhalation to orthotopic M109-HiFR lung tumor grafted mice. Paclitaxel-loaded F-PEG-HMD micelles characterized in PBS by a Z-average diameter of ∼50nm and a zeta potential of ∼−4mV were prepared with an encapsulation efficiency of ∼100%....
全文获取路径: Elsevier  (合作)
影响因子:3.458 (2012)

  • micelle 胶束
  • powders 粉料
  • chemotherapy 化学疗法
  • polymeric 聚合的
  • loaded 加负荷的
  • polyethylene 聚乙烯
  • encapsulation 密封
  • spray 喷雾
  • diameter 直径
  • deposition 沉积