M1 and M2 macrophage polarization and potentially therapeutic naturally occurring compounds
作者: Youhan WangWanli SmithDingjun HaoBaorong HeLingbo Kong
作者单位: 1Department of Spine Surgery, Honghui-hospital, Xi'an Jiaotong Uinversity, School of Medicine, Xi'an, China
2Shaanxi University of Chinese Medicine, Xian Yang, China
3Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA
刊名: International Immunopharmacology, 2019, Vol.70 , pp.459-466
来源数据库: Elsevier Journal
DOI: 10.1016/j.intimp.2019.02.050
关键词: Naturally occurring compoundsMacrophageInflammationM1M2
英文摘要: Abstract(#br)Macrophages, as crucial cellular components of innate immunity, are characterized by possessing high plasticity and an abnormal ability to differentiate in response to numerous stimuli. Given this, macrophages show extreme heterogeneity under both physiological and pathological conditions. Typically, macrophages can be polarized into classically activated macrophages (M1) and alternatively activated macrophages (M2) depending on their environment. The relative functions of these two subtypes are almost exactly opposed to one another. Recent studies have suggested that some naturally occurring compounds can exert regulatory effects on the progression of macrophage polarization, which implies that they could be promising therapeutic tools to treat relevant diseases. Therefore,...
全文获取路径: Elsevier  (合作)
影响因子:2.417 (2012)

  • potentially 可能地
  • therapeutic 治疗的
  • macrophage 巨噬细胞
  • polarization 极化
  • naturally 当然
  • compounds 化合物