Development and evaluation of new sustained-release floating microspheres
作者: Ninan MaLu XuQifang WangXiangrong ZhangWenji ZhangYang LiLingyu JinSanming Li
作者单位: 1School of Pharmacy, Shenyang Pharmaceutical University, Wen Hua Road, No. 103, Shenyang 110016, Liaoning Province, People's Republic of China
刊名: International Journal of Pharmaceutics, 2008, Vol.358 (1), pp.82-90
来源数据库: Elsevier Journal
DOI: 10.1016/j.ijpharm.2008.02.024
关键词: Floating drug delivery systemSustained-releaseAlginate microsphereGamma-scintigraphy
原始语种摘要: Abstract(#br)A type of multi-unit floating alginate (Alg) microspheres was prepared by the ionotropic gelation method with calcium carbonate (CaCO 3 ) being used as gas-forming agent. Attempts were made to enhance the drug encapsulation efficiency and delay the drug release by adding chitosan (Cs) into the gelation medium and by coating with Eudragit, respectively. The gastrointestinal transit of optimized floating sustained-release microspheres was compared with that of the non-floating system manufactured from identical material using the technique of gamma-scintigraphy in healthy human volunteers. It was found that the drug encapsulation efficiency of Cs–Alg microspheres was much higher than that of the Ca–Alg microspheres, and coating the microspheres with Eudragit RS could extend the...
全文获取路径: Elsevier  (合作)
影响因子:3.458 (2012)

  • floating 浮动的
  • release 释放
  • coating 覆盖层
  • system 
  • evaluation 评价
  • efficiency 效率
  • manufactured 出品
  • volunteer 志愿兵
  • sustained 持续的
  • gelation 软胶化