Involvement of the prostaglandin D2 signal pathway in retinoid-inducible gene 1 (RIG1)-mediated suppression of cell invasion in testis cancer cells
作者: Chang-Chieh WuRong-Yaun ShyuChun-Hua WangTzung-Chieh TsaiLu-Kai WangMao-Liang ChenShun-Yuan JiangFu-Ming Tsai
作者单位: 1Department of Surgery, Tri-Service General Hospital, Taipei 114, Taiwan
2Department of Internal Medicine, Buddhist Tzu Chi General Hospital Taipei Branch, New Taipei City 231, Taiwan
3Department of Dermatology, Buddhist Tzu Chi General Hospital Taipei Branch, New Taipei City 231, Taiwan
4Department of Microbiology, Immunology and Biopharmaceuticals, National Chiayi University, Chiayi, Taiwan
5Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan
6Department of Research, Buddhist Tzu Chi General Hospital, Taipei Branch, New Taipei City 231, Taiwan
刊名: BBA - Molecular Cell Research, 2012, Vol.1823 (12), pp.2227-2236
来源数据库: Elsevier Journal
DOI: 10.1016/j.bbamcr.2012.08.013
关键词: Retinoid-inducible gene 1Prostaglandin D2 synthaseTestisHREV107 type II tumor suppressor
原始语种摘要: Abstract(#br)Retinoid-inducible gene 1 (RIG1), also called tazarotene-induced gene 3, belongs to the HREV107 gene family, which contains five members in humans. RIG1 is expressed in high levels in well-differentiated tissues, but its expression is decreased in cancer tissues and cancer cell lines. We found RIG1 to be highly expressed in testicular cells. When RIG1 was expressed in NT2/D1 testicular cancer cells, neither cell death nor cell viability was affected. However, RIG1 significantly inhibited cell migration and invasion in NT2/D1 cells. We found that prostaglandin D2 synthase (PTGDS) interacted with RIG1 using yeast two-hybrid screens. Further, we found PTGDS to be co-localized with RIG1 in NT2/D1 testis cells. In RIG1-expressing cells, elevated levels of prostaglandin D2 (PGD2),...
全文获取路径: Elsevier  (合作)

  • cells 麻风细胞
  • testis 睾丸
  • suppression 抑制
  • synthase 合酶
  • expressed 榨出的
  • invasion 侵入
  • expression 表示
  • migration 迁移
  • prostaglandin 前列腺素
  • observed 观察到的