Association between the variable number of tandem repeat polymorphism in the third exon of the dopamine D 4 receptor gene and sensitivity to analgesics and pain in patients undergoing painful cosmetic surgery
作者: Yoshinori AokiDaisuke NishizawaShinya KasaiKen-ichi FukudaTatsuya IchinoheShuichiro YamashitaKazutaka Ikeda
作者单位: 1Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan
2Department of Oral Health and Clinical Science, Division of Dental Anesthesiology (Orofacial Pain Center/Suidoubashi Hospital), Tokyo Dental College, 2-9-18 Misaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan
3Department of Dental Anesthesiology, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba 261-8502, Japan
4Department of Oral Health and Clinical Science, Division of Prosthodontics, Tokyo Dental College, 2-9-18 Misaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan
刊名: Neuroscience Letters, 2013, Vol.542 , pp.1-4
来源数据库: Elsevier Journal
DOI: 10.1016/j.neulet.2013.02.039
关键词: Dopamine D 4 receptorJapaneseOpioidPCAPostoperative painVNTR
原始语种摘要: Abstract(#br)To elucidate the mechanisms of individual differences in pain and analgesic sensitivity, we analyzed the variable number of tandem repeat polymorphism in the third exon of the dopamine D 4 receptor gene. Alleles that were less than four repeats long and four or more repeats long were considered Short and Long, respectively. We found that the Short/Short genotype group was significantly more sensitive to pain and less sensitive to analgesics than the Short/Long+Long/Long genotype group. Our data suggest that this polymorphism may predict individual differences in pain and analgesic sensitivity and help achieve adequate pain control in the future.
全文获取路径: Elsevier  (合作)
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影响因子:2.026 (2012)

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关键词翻译
关键词翻译
  • analgesics 镇痛药
  • dopamine 多巴胺
  • painful 痛苦的
  • tandem 串联机
  • receptor 接受体
  • sensitivity 灵敏度
  • repeat 中继
  • variable 变量
  • VNTR 变数串联重复
  • predict 预见